Hla typing in patients of Eales disease

To determine any predisposition of haplotypes with Eales disease. A case control study. This study was started in February 2002 and data collected till April 2003 at Eye Department of Military Hospital, Rawalpindi. The frequency of HLA antigens both class-1 and II by complement dependent st and ard lymphocytotoxicity test was studied in 32 patients of Eales disease [group-1] and 32 age and gender matched normal persons as controls [group-11]. Both patients and controls underwent complete ocular and clinical examination and were followed up for one year. Mean age was 30.8 years. HLA DR3 was found in 20 patients of group-1 and none in group-11. HLA types A1, B8, B5 [51] and DR 15 [2] were found in 12 out of 32 patients of eales disease and none in controls. HLA DQ2 and DR52 was found in 28 cases of group-l as compared to 18 cases of group-ll [p=.005]. HLA phenotypes HLA DR3, A1, B8, B5 [51] and DR 15 [2] occurred in majority of cases of Eales disease, whereas these were not found in controls which was statistically significant. Similarly, HLA DQ2, DR52 and Bw6 was found in higher frequency in Eales patients and thus strongly associated with it. We conclude that certain HLA haplotypes have a possible predilection for Eales disease

Serum electrophoresis in patients of Eale's disease

Eales disease is an obliterative vasculopathy that usually involve peripheral retina of young adults. It is thought to be a nonspecific tissue response to a number of agents and exact etiology remains unknown. Many diseases reflect some alterations in electrophoretic pattern of serum proteins. This study was carried out to investigate electrophoretic pattern of serum proteins in Eales disease so as to throw some light on possible etiological factors in these patients. Thirty-two patients of Eales disease constituted the subject material for this study. Paper electrophoresis of the sera was performed by cellulose acetate method on Whatman filter paper No.10 using barbitone buffer of pH 8.6. Both patients and controls underwent complete ocular and clinical examination and followed up for one year. This was a descriptive study. Ten patients [30%] had raised total serum proteins out of 32 patients and ten patients [30%] had raised gamma globulin. Serum albumin was decreased in seven patients [20%] out of thirty-two patients of Eales disease. In our study 30% increase in total serum proteins and gamma globulins in Eales disease patients points to a possible role of some immunological process which manifests as retinal perivasculitis in eyes. An increase in erythrocyte sedimentation rate in >85% of cases is consistent with this suggestion

Pseudoexfoliation syndrome and secondary catract

Pseudoexfoliation syndrome is a relatively common degenerative disorder, wherein a grey-white, fibrillogranular material is deposited in and around the anterior segment of the eye especially on the anterior lens surface, iris border and cornea. This can cause inflammation in the eye causing complicated cataract and secondary glaucoma We conducted this study to find out the frequency of complicated cataracts in such cases. Two hundred and seventy five cases with pseudoexfoliation syndrome presenting in the Dept of Ophthalmology, Military Hospital, Rawalpindi were taken up in the study and their detailed anterior chamber examination was done with special emphasis on the presence of cataract after maximal pupillary dilatation. Eighty cases [29.09%] showed the presence of cataract in their involved eyes. The occurrence of cataract in a significant number of cases suggests careful preoperative attention to zonular integrity if lens extraction is contemplated